{"id":8585,"date":"2020-09-21T06:21:36","date_gmt":"2020-09-21T11:21:36","guid":{"rendered":"https:\/\/cornflowerblue-rail-980953.hostingersite.com\/?p=8585"},"modified":"2020-09-21T06:21:36","modified_gmt":"2020-09-21T11:21:36","slug":"whats-new-in-liver-imaging-french-september-2020","status":"publish","type":"post","link":"https:\/\/staging-hub.acoredu.com\/fr\/whats-new-in-liver-imaging-french-september-2020\/","title":{"rendered":"What&rsquo;s new in Liver Imaging (French) &#8211; September 2020"},"content":{"rendered":"<p>&nbsp;<\/p>\n<h3><span style=\"color: #800080;\"><strong>CHC <\/strong><\/span><\/h3>\n<p>&nbsp;<\/p>\n<h5><span style=\"color: #3366ff;\"><strong>Performances diagnostiques de l&rsquo;algorithme de r\u00e9ponse au traitement LI-RADS pour le carcinome h\u00e9patocellulaire: ajout de caract\u00e9ristiques auxiliaires \u00e0 l&rsquo;IRM par rapport aux patterns de rehaussement au CT et \u00e0 l&rsquo;IRM<\/strong><\/span><\/h5>\n<p>Park, S., Joo, I., Lee, D. H., Bae, J. S., Yoo, J., Kim, S. W., &amp; Lee, J. M. (2020).<\/p>\n<p>Diagnostic performance of LI-RADS treatment response algorithm for hepatocellular carcinoma: adding ancillary features to MRI compared with enhancement patterns at CT and MRI. Radiology, 192797.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1148\/radiol.2020192797\">https:\/\/doi.org\/10.1148\/radiol.2020192797<\/a><\/p>\n<p><strong>Question clinique: <\/strong>Comparer les performances diagnostiques des crit\u00e8res auxiliaires \u00e0 l\u2019IRM concernant l\u2019ajustement de cat\u00e9gorie avec l&rsquo;algorithme LR-TR au CT et \u00e0 l\u2019IRM pour la d\u00e9tection de la viabilit\u00e9 tumorale.<\/p>\n<p><strong>M\u00e9thode: <\/strong>\u00c9tude r\u00e9trospective entre 2014 et 2017 de 138 patients atteints de CHC trait\u00e9s par th\u00e9rapie locor\u00e9gionale suivie de r\u00e9section chirurgicale ou d&rsquo;une transplantation h\u00e9patique. Des cat\u00e9gories de r\u00e9ponse au traitement ont \u00e9t\u00e9 attribu\u00e9es pour chaque observation trait\u00e9e, sur la base de l&rsquo;algorithme LR-TR au CT et \u00e0 l\u2019IRM, et selon l&rsquo;algorithme TR IRM-modifi\u00e9 avec l&rsquo;application de crit\u00e8res auxiliaires \u00e0 l\u2019IRM pour l&rsquo;ajustement de la cat\u00e9gorie.<\/p>\n<p><strong>Constatations et r\u00e9sultats: <\/strong>La sensibilit\u00e9 et la sp\u00e9cificit\u00e9 des cat\u00e9gories LR-TR au CT et \u00e0 l\u2019IRM pour pr\u00e9dire la viabilit\u00e9 tumorale \u00e9taient de 73% contre 76% et 90% contre 83%, respectivement. La cat\u00e9gorie de viabilit\u00e9 TR IRM-modifi\u00e9e avait une sensibilit\u00e9 plus \u00e9lev\u00e9e (84%) que les cat\u00e9gories de viabilit\u00e9 LR-TR pour le CT et l\u2019IRM, sans diff\u00e9rence de sp\u00e9cificit\u00e9.<\/p>\n<p><strong>Conclusion<\/strong>: L&rsquo;application des crit\u00e8res auxiliaires d\u2019IRM \u00e0 l&rsquo;algorithme LI-RADS TR a entra\u00een\u00e9 une sensibilit\u00e9 plus \u00e9lev\u00e9e et aucun changement de sp\u00e9cificit\u00e9 par rapport aux patterns de rehaussement CT ou IRM seuls dans la pr\u00e9diction de la viabilit\u00e9 des tumeurs pathologiques.<\/p>\n<p><strong>Implications: <\/strong>Compte tenu de la sensibilit\u00e9 accrue de l&rsquo;algorithme LI-RADS TR avec l&rsquo;ajout de crit\u00e8res auxiliaires \u00e0 l\u2019IRM, les prochaines mises \u00e0 jour de LI-RADS pourraient inclure l&rsquo;utilisation facultative des crit\u00e8res auxiliaires d\u2019IRM pour une meilleure pr\u00e9cision du diagnostic.<\/p>\n<p>&nbsp;<\/p>\n<h5><span style=\"color: #3366ff;\"><strong>Application des crit\u00e8res auxiliaires de la version 2018 du <em>Liver Imaging Reporting and Data System<\/em> pour passer du LR-4 \u00e0 LR-5 sur l&rsquo;IRM inject\u00e9 \u00e0 l&rsquo;acide gadox\u00e9tique<\/strong><\/span><\/h5>\n<p>Lee S, Kim SS, Bae H, Shin J, Yoon JK, Kim MJ.<\/p>\n<p>Application of Liver Imaging Reporting and Data System version 2018 ancillary features to upgrade from LR-4 to LR-5 on gadoxetic acid-enhanced MRI [published online ahead of print, 2020 Aug 18].<\/p>\n<p>Eur Radiol. 2020;10.1007\/s00330-020-07146-4.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1007\/s00330-020-07146-4\">https:\/\/doi.org\/10.1007\/s00330-020-07146-4<\/a><\/p>\n<p><strong>Mots clefs:<\/strong> Contrast media; Diagnosis; Liver neoplasms; Magnetic resonance imaging; Sensitivity and specificity.<\/p>\n<p><strong>Question clinique:<\/strong> Pouvons-nous utiliser les crit\u00e8res IRM auxiliaires pour passer du LR-4 au LR-5?<\/p>\n<p><strong>Ce qui a \u00e9t\u00e9 fait<\/strong>: Les performances diagnostiques du LR-5 am\u00e9lior\u00e9 (utilisant les crit\u00e8res IRM auxiliaires du LR-4) ont \u00e9t\u00e9 compar\u00e9es \u00e0 celles du LR-5 standard.<\/p>\n<p><strong>M\u00e9thode<\/strong>: Etude r\u00e9trospective de 280 patients \u00e0 haut risque de CHC qui ont subi une IRM-Gd entre 2015 et 2017. Les crit\u00e8res auxiliaires ind\u00e9pendants significatifs ont \u00e9t\u00e9 identifi\u00e9s. Les nouveaux crit\u00e8res LR-5 ont \u00e9t\u00e9 d\u00e9velopp\u00e9s en combinant les crit\u00e8res auxiliaires ind\u00e9pendants significatifs avec uniquement les crit\u00e8res majeurs du LR-4. Les sensibilit\u00e9s et sp\u00e9cificit\u00e9s des crit\u00e8res diagnostiques ont \u00e9t\u00e9 compar\u00e9es.<\/p>\n<p><strong>Constatations et r\u00e9sultats:<\/strong> Quatre crit\u00e8res auxiliaires (hyperintensit\u00e9 T2 l\u00e9g\u00e8re \u00e0 mod\u00e9r\u00e9e et hypointensit\u00e9 de la phase h\u00e9patobiliaire, capsule non-rehaussante et architecture en mosa\u00efque) \u00e9taient les caract\u00e9ristiques ind\u00e9pendantes significatives pour le diagnostic du CHC. En ajoutant ces nouveaux crit\u00e8res au LR-5, les sensibilit\u00e9s \u00e9taient significativement augment\u00e9es (69,4-76,9%) par rapport au LR-5 standard (66,2%), alors que les sp\u00e9cificit\u00e9s n&rsquo;\u00e9taient pas significativement diff\u00e9rentes.<\/p>\n<p><strong>Conclusion:<\/strong> Certains crit\u00e8res auxiliaires ind\u00e9pendants peuvent \u00eatre utilis\u00e9s pour upgrader de LR-4 \u00e0 LR-5 en am\u00e9liorant la sensibilit\u00e9 sans alt\u00e9rer la sp\u00e9cificit\u00e9 sur Gd-IRM.<\/p>\n<p><strong>Implications:<\/strong> Depuis le d\u00e9but de LI-RADS, la cat\u00e9gorie LR-5 n&rsquo;est attribu\u00e9e que sur la base des crit\u00e8res majeurs et les crit\u00e8res auxiliaires ne pouvaient pas \u00eatre utilis\u00e9s pour mettre \u00e0 niveau le LR-4 vers le LR-5 tout en maintenant la haute sp\u00e9cificit\u00e9 de LR-5 pour le HCC. Cette \u00e9tude r\u00e9trospective indique que certains crit\u00e8res auxiliaires peuvent \u00eatre utilis\u00e9s pour am\u00e9liorer le LR-4 avec une sensibilit\u00e9 am\u00e9lior\u00e9e et une sp\u00e9cificit\u00e9 maintenue.<\/p>\n<p>&nbsp;<\/p>\n<h3><span style=\"color: #800080;\"><strong>TECHNIQUES D&rsquo;IMAGERIE DU FOIE<\/strong><\/span><\/h3>\n<p><strong>\u00a0<\/strong><\/p>\n<h5><span style=\"color: #3366ff;\"><strong>\u00c9chographie inject\u00e9e avec de l&rsquo;hexafluorure de soufre et du perfluorobutane pour le diagnostic du carcinome h\u00e9patocellulaire chez les personnes \u00e0 haut risque<\/strong><\/span><\/h5>\n<p>Kang, H. J., Lee, J. M., Yoon, J. H., Lee, K., Kim, H., &amp; Han, J. K. (2020).<\/p>\n<p>Contrast-enhanced US with Sulfur Hexafluoride and Perfluorobutane for the Diagnosis of Hepatocellular Carcinoma in Individuals with High Risk.<\/p>\n<p>Radiology, 200115.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1148\/radiol.2020200115\">https:\/\/doi.org\/10.1148\/radiol.2020200115<\/a><\/p>\n<p><strong>Question clinique: <\/strong>Les \u00e9chographies inject\u00e9es au perfluorobutane (PFB) sont-elles sup\u00e9rieures aux \u00e9chographies inject\u00e9es \u00e0 l&rsquo;hexafluorure de soufre (SHF) dans le diagnostic du CHC?<\/p>\n<p><strong>Ce qui a \u00e9t\u00e9 fait:<\/strong> Les performances diagnostiques de l\u2019\u00e9chographie inject\u00e9e avec du PFB versus du SHF ont \u00e9t\u00e9s compar\u00e9es avec la m\u00e9thode CEUS LI-RADS v2017.<\/p>\n<p><strong>M\u00e9thode:<\/strong> \u00c9tude prospective de 59 patients \u00e0 haut risque de CHC avec des observations h\u00e9patiques suspectes (LR-3, LR-4, LR-5 et LR-M) qui ont subi une \u00e9chographie inject\u00e9e au PFB et au SHF la m\u00eame journ\u00e9e. L&rsquo;APHE (Arterial Phase non-rim Hyperenhancement), le temps et le degr\u00e9 de lavement (washout) du contraste et l&rsquo;\u00e9chog\u00e9nicit\u00e9 dans la phase de Kupffer ont \u00e9t\u00e9 \u00e9valu\u00e9s et cat\u00e9goris\u00e9s \u00e0 l&rsquo;aide du CEUS LI-RADS v2017. Les performances diagnostiques des deux techniques ont \u00e9t\u00e9 compar\u00e9es.<\/p>\n<p><strong>Constatations et r\u00e9sultats:<\/strong> L\u2019APHE \u00e9tait similaire avec les deux agents de contraste. Les washouts tardifs et l\u00e9gers \u00e9taient plus fr\u00e9quents avec le PFB. Le temps de washout pour les HCC \u00e9tait plus tardif avec le PFB qu\u2019avec le SHF. La sensibilit\u00e9 (79%) du PFB \u00e9tait sup\u00e9rieure que celle du SHF (54%). La sp\u00e9cificit\u00e9 \u00e9tait de 100% avec les deux.<\/p>\n<p><strong>Conclusion:<\/strong> L\u2019utilisation du CEUS LI-RADS avec du PFB aurait une sensibilit\u00e9 significativement plus \u00e9lev\u00e9e qu\u2019avec du SHF, sans baisse de sp\u00e9cificit\u00e9.<\/p>\n<p><strong>Implications:<\/strong> Le CEUS LI-RADS v2017 s&rsquo;applique actuellement aux agents de pooling sanguin purs tels que le SHF, mais pas aux agents combin\u00e9s de pooling sanguin\/cellules de Kupffer tels que le PFB. Bien que le PFB ne soit pas encore approuv\u00e9 pour imagerie h\u00e9patique aux \u00c9tats-Unis, il offre de meilleures performances diagnostiques que le SHF traditionnellement utilis\u00e9. L\u2019impl\u00e9mentation du PFB aux \u00c9tats-Unis pourrait \u00eatre n\u00e9cessaire dans un proche avenir.<\/p>\n<p>&nbsp;<\/p>\n<h5><span style=\"color: #3366ff;\"><strong>Syst\u00e8me pour rapporter les donn\u00e9es d&rsquo;imagerie h\u00e9patique par \u00e9chographie avec contraste pour le diagnostic du carcinome h\u00e9patocellulaire: une m\u00e9ta-analyse<\/strong><\/span><\/h5>\n<p>Shin, J., Lee, S., Bae, H., Chung, Y. E., Choi, J. Y., Huh, Y. M., &amp; Park, M. S. (2020).<\/p>\n<p>Contrast-enhanced ultrasound liver imaging reporting and data system for diagnosing hepatocellular carcinoma: A meta-analysis.<\/p>\n<p>Liver international: official journal of the International Association for the Study of the Liver, 10.1111\/liv.14617.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1111\/liv.14617\">https:\/\/doi.org\/10.1111\/liv.14617<\/a><\/p>\n<p><strong>Mots clefs:<\/strong> diagnosis; liver neoplasms; microbubbles; sensitivity and specificity; ultrasound.<\/p>\n<p><strong>Question clinique:<\/strong> Quelle est la performance diagnostique du CEUS LR-5 pour le CHC?<\/p>\n<p><strong>Ce qui a \u00e9t\u00e9 fait:<\/strong> Les performances diagnostiques du CEUS LR-5 et la proportion de CHC dans chaque cat\u00e9gorie du CEUS LI-RADS ont \u00e9t\u00e9 \u00e9valu\u00e9es.<\/p>\n<p><strong>M\u00e9thode:<\/strong> M\u00e9ta-analyse de 11 \u00e9tudes incluant un total de 5535 observations, dont 3983 \u00e9taient des CHC. Un mod\u00e8le \u00e0 effets al\u00e9atoires a \u00e9t\u00e9 utilis\u00e9 pour estimer la performance diagnostique du CEUS LR-5 et les proportions regroup\u00e9es de CHC dans chaque cat\u00e9gorie CEUS LI-RADS. Le risque de biais et les pr\u00e9occupations concernant l&rsquo;applicabilit\u00e9 ont \u00e9t\u00e9 \u00e9valu\u00e9s.<\/p>\n<p><strong>Constatations et r\u00e9sultats:<\/strong> La sensibilit\u00e9 et la sp\u00e9cificit\u00e9 regroup\u00e9es du LR-5 pour le diagnostic du CHC \u00e9taient de 69% et 92%, respectivement. Les proportions de CHC \u00e9taient de 0% pour LR-1, 1% pour LR-2, 26% pour LR-3, 77% pour LR-4, 97% pour CEUS LR-5 et 57% pour LR-M.<\/p>\n<p><strong>Conclusion:<\/strong> La cat\u00e9gorie LR-5 a montr\u00e9 une sensibilit\u00e9 mod\u00e9r\u00e9e et une sp\u00e9cificit\u00e9 \u00e9lev\u00e9e pour le diagnostic du CHC.<\/p>\n<p><strong>Implications:<\/strong> Le CEUS LI-RADS peut \u00eatre utilis\u00e9 avec confiance pour diagnostiquer le CHC.<\/p>\n<p>&nbsp;<\/p>\n<h3><strong><span style=\"color: #800080;\">FOIE: SCIENCE FONDAMENTALE<\/span><\/strong><\/h3>\n<p><strong>\u00a0<\/strong><\/p>\n<h5><span style=\"color: #3366ff;\"><strong>\u00c9valuation de l&rsquo;h\u00e9patite et de la fibrose par IRM Gd-EOB-DTPA chez le chien.<\/strong><\/span><\/h5>\n<p>Tanaka, T., Nishida, H., Mie, K., Yamazaki, H., Lin, L. S., &amp; Akiyoshi, H. (2020).<\/p>\n<p>Assessment of hepatitis and fibrosis using Gd-EOB-DTPA MRI in dogs. Veterinary record open, 7(1), e000371.<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1136\/vetreco-2019-000371\">https:\/\/doi.org\/10.1136\/vetreco-2019-000371<\/a><\/p>\n<p><strong>Mots clefs:<\/strong> gadoxetate sodium; hepatocellular adenoma; hepatocellular carcinoma; liver function; magnetic resonance imaging (MRI); nodular hyperplasia.<\/p>\n<p><strong>Question clinique:<\/strong> L\u2019administration de contraste Gd-EOB-DTPA en IRM est-elle corr\u00e9l\u00e9e \u00e0 la fonction h\u00e9patique chez le chien?<\/p>\n<p><strong>Ce qui a \u00e9t\u00e9 fait:<\/strong> L\u2019intensit\u00e9 relative du signal (IRS) du canal chol\u00e9doque et de la v\u00e9sicule biliaire ont \u00e9t\u00e9 calcul\u00e9es, et leur relation avec les param\u00e8tres biochimiques de la fonction h\u00e9patique a \u00e9t\u00e9 \u00e9valu\u00e9e. Les indices relatifs de rehaussement du contraste (IRRC) du foie ont \u00e9t\u00e9 calcul\u00e9s, et les diff\u00e9rences entre le foie normal et malade ont \u00e9t\u00e9 \u00e9valu\u00e9es.<\/p>\n<p><strong>M\u00e9thode:<\/strong> Etude r\u00e9trospective sur 16 chiens atteints d&rsquo;une maladie h\u00e9patique histologiquement prouv\u00e9e (CHC, hyperplasie nodulaire, ad\u00e9nome h\u00e9patocellulaire, fibrose h\u00e9patique et h\u00e9patite). L\u2019IRS du canal chol\u00e9doque et de la v\u00e9sicule biliaire a \u00e9t\u00e9 calcul\u00e9. La moyenne de l\u2019intensit\u00e9 du signal (IS) dans le foie a \u00e9t\u00e9 calcul\u00e9e pendant la phase h\u00e9patobiliaire et consid\u00e9r\u00e9e comme repr\u00e9sentative du parenchyme h\u00e9patique. La relation entre ces indices et les marqueurs biochimiques de la fonction h\u00e9patique a \u00e9t\u00e9 \u00e9valu\u00e9e (bilirubine totale, alanine transaminase, phosphatase alcaline et albumine).<\/p>\n<p><strong>Constatations et r\u00e9sultats:<\/strong> L\u2019IRS n&rsquo;a montr\u00e9 aucune diff\u00e9rence significative entre les chiens avec et sans diagnostic histopathologique de maladie du foie, bien qu&rsquo;ils soient significativement corr\u00e9l\u00e9s avec l&rsquo;albumine (\u03c1=0.57) \u00a0chez les chiens avec un diagnostic histopathologique de maladie du foie. L\u2019IRRC \u00e9tait significativement plus \u00e9lev\u00e9 dans le tissu h\u00e9patique normal que dans les foies atteints d&rsquo;h\u00e9patite\/fibrose et de CHC, mais pas avec l\u2019hyperplasie nodulaire ni avec les ad\u00e9nomes h\u00e9patocellulaires.<\/p>\n<p><strong>Conclusions:<\/strong> L\u2019ISR du canal chol\u00e9doque et de la v\u00e9sicule biliaire est corr\u00e9l\u00e9 \u00e0 l&rsquo;albumine chez les chiens atteints d&rsquo;une maladie du foie. L\u2019IRRC de la phase h\u00e9patobiliaire est plus \u00e9lev\u00e9 dans le foie normal que dans l&rsquo;h\u00e9patite et la fibrose.<\/p>\n<p><strong>Implications:<\/strong> L&rsquo;IRM Gd-EOB-DTPA est potentiellement utile pour \u00e9valuer l&rsquo;h\u00e9patite et la fibrose h\u00e9patique chez le chien. Cependant, d&rsquo;autres \u00e9tudes sont n\u00e9cessaires pour valider cela chez l&rsquo;homme.<\/p>\n","protected":false},"excerpt":{"rendered":"&nbsp; CHC &nbsp; Performances diagnostiques de l&rsquo;algorithme de r\u00e9ponse au traitement LI-RADS pour le carcinome [&hellip;]","protected":false},"author":3,"featured_media":2950,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[205],"tags":[],"class_list":["post-8585","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classifiee"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>What&#039;s new in Liver Imaging (French) - September 2020 - ACORE<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/staging-hub.acoredu.com\/whats-new-in-liver-imaging-september-2020\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What&#039;s new in Liver Imaging (French) - September 2020 - ACORE\" \/>\n<meta property=\"og:description\" content=\"&nbsp; 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